(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

Base Information

Chemical Name:(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde
CAS No.:1308339-05-0
Molecular Formula:C₂₉H₂₉FN₂O₄
Molecular Weight:488.559
Hs Code.:

Synonyms:(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

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Chemical Property of (S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

Chemical Property:

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Technology Process of (S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

There total 5 articles about (S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone

: 1308339-05-0
(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

Guidance literature:: (S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 0.25h;

With triethylamine; In dichloromethane; at -60 - 20 ℃;

Reference yield:

: 74163-81-8
L-Tic-OH

: 1308339-05-0
(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / N,N-dimethyl-formamide / 2 h

2.1: dmap; diisopropyl-carbodiimide / dichloromethane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 120 °C / Microwave irradiation

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -60 °C

4.2: -60 - 20 °C

With dmap; oxalyl dichloride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1308338-96-6
(S)-perfluorophenyl 2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 1308339-05-0
(S)-2-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 120 °C / Microwave irradiation

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -60 °C

2.2: -60 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;