2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

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Chemical Name:2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one
CAS No.:1330784-49-0
Molecular Formula:C₃₄H₂₈F₃N₅OS
Molecular Weight:611.69
Hs Code.:

Synonyms:2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of 2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

There total 6 articles about 2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474706-58-6
(3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl)boronic acid

: 1330782-90-5
6-bromo-2-(pyrrolidin-1-ylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

: 1330784-49-0
2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; at 80 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1330782-89-2
6-bromo-2-(chloromethyl)thieno[3,2-d]pyrimidin-4(3H)-one

: 1330784-49-0
2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.5 h / 70 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 80 °C / Inert atmosphere

With sodium carbonate; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1330784-49-0
2-(pyrrolidin-1-ylmethyl)-6-[3-(trifluoromethyl)-1-trityl-1H-pyrazol-4-yl]thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / acetonitrile / 0 - 20 °C / Cooling with ice

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium carbonate; methanol / water / 2 h / 20 °C

4.1: hydrogenchloride / cyclopentylmethylether / 3 h / 20 - 70 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.5 h / 70 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; n-butyllithium; sodium carbonate; potassium carbonate; diisopropylamine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; cyclopentylmethylether; water; N,N-dimethyl-formamide; acetonitrile;