lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

Base Information

Chemical Name:lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate
CAS No.:1403384-93-9
Molecular Formula:C₂₃H₂₅N₂O₅*Li
Molecular Weight:416.403
Hs Code.:

Synonyms:lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

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Chemical Property of lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

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Technology Process of lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

There total 5 articles about lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301198-71-9
methyl 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

: 1403384-93-9
lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

Guidance literature:: With lithium hydroxide; In methanol; at 40 ℃; for 6h;

Reference yield:

: 1300031-94-0
1-methylethyl {(3S)-3-[(4-bromophenyl)amino]butanoyl}carbamate

: 1403384-93-9
lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 2 h / -10 - 20 °C

2: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 100 °C

4: lithium hydroxide / methanol / 6 h / 40 °C

With pyridine; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; potassium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1300031-97-3
1-methylethyl (2E)-2-butenoylcarbamate

: 1403384-93-9
lithium 4-((2S,4R)-1-acetyl-4-((isopropoxycarbonyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: ((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)ditriflatebis(acetonitrile)palladium(ll) / toluene / 16.33 h / Inert atmosphere

2: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 2 h / -10 - 20 °C

3: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 100 °C

5: lithium hydroxide / methanol / 6 h / 40 °C

With pyridine; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; potassium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)ditriflatebis(acetonitrile)palladium(ll); In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;