N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

Base Information

Chemical Name:N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide
CAS No.:280781-55-7
Molecular Formula:C₃₂H₃₉N₅O₅S
Molecular Weight:605.758
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

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Chemical Property of N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

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Technology Process of N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

There total 8 articles about N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 280781-54-6
N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl-[(5-cyano-2-thienyl)methyl]amide

: 280781-55-7
N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In ethanol; for 1h; Heating;
DOI:10.1021/jm030025j

Reference yield:

: 765-58-2
2-bromo-5-methyl thiophene

: 280781-55-7
N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

Guidance literature:: Multi-step reaction with 8 steps

1: dimethylformamide / Heating

2: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 6 h / Heating

3: NaH / tetrahydrofuran / 3 h

4: 2.4 g / HCl(g) / ethyl acetate / 0 - 20 °C

5: 86 percent / EDC; HOBT; Et₃N / dimethylformamide / 20 °C

6: 100 percent / HCl / ethyl acetate / 3 h / 20 °C

7: 72 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

8: 96 percent / aq. NH₂OH*HCl; Na₂CO₃ / ethanol / 1 h / Heating

With hydrogenchloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j

Reference yield:

: 72835-25-7
2-cyano-5-methylthiophene

: 280781-55-7
N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 6 h / Heating

2: NaH / tetrahydrofuran / 3 h

3: 2.4 g / HCl(g) / ethyl acetate / 0 - 20 °C

4: 86 percent / EDC; HOBT; Et₃N / dimethylformamide / 20 °C

5: 100 percent / HCl / ethyl acetate / 3 h / 20 °C

6: 72 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

7: 96 percent / aq. NH₂OH*HCl; Na₂CO₃ / ethanol / 1 h / Heating

With hydrogenchloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j