1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

Base Information

Chemical Name:1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione
CAS No.:1228659-44-6
Molecular Formula:C₂₅H₂₉F₃N₄O₂
Molecular Weight:474.526
Hs Code.:

Synonyms:1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

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Chemical Property of 1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

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Technology Process of 1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

There total 9 articles about 1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1228660-67-0
2-bromo-6-(3,3-difluoropiperidin-1-ylmethyl)-3-fluoropyridine

: 1228594-56-6
3-isobutyl-1-(4-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)-benzyl)imidazolidine-2,4-dione

: 1228659-44-6
1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 75 ℃; for 17h; Inert atmosphere;
DOI:10.1021/jm200916p

Reference yield:

: 201987-81-7
1-(4-bromobenzyl)imidazolidine-2,4-dione

: 1228659-44-6
1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 50 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 17 h / 75 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 17 h / 75 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1021/jm200916p

Reference yield:

: 850859-09-5
2-(4-bromobenzylamino)acetamide

: 1228659-44-6
1-(4-(6-((3,3-difluoropiperidin-1-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / acetonitrile / 16 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 50 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 17 h / 75 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 17 h / 75 °C / Inert atmosphere

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4: Suzuki coupling;
DOI:10.1021/jm200916p