N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester
• CAS No.: 1190208-77-5
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.326
• Mol file: 1190208-77-5.mol

Synonyms:N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester

Chemical Property of N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester

There total 4 articles about N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-ethanol (106899-00-7) → N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester (1190208-77-5)

Guidance literature:

In tetrahydrofuran; Reflux;

DOI:10.1016/j.tetasy.2009.06.024

Reference yield:

C20H35NO3Si → N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester (1190208-77-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jacs.0c07490

Reference yield:

2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N-methylaniline → N-[2-(2-hydroxyethyl)phenyl]-N-methylcarbamic acid tert-butyl ester (1190208-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 6 h / 50 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jacs.0c07490

upstream raw materials:

di-tert-butyl dicarbonate

2-ethanol

2-aminophenethyl alcohol

Downstream raw materials:

N-methyl-N-[2-(2-oxoethyl)phenyl]carbamic acid tert-butyl ester