(R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile

Base Information

• Chemical Name: (R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile
• CAS No.: 1447034-75-4
• Molecular Formula: C₂₄H₂₄N₂
• Molecular Weight: 340.468
• Mol file: 1447034-75-4.mol

Synonyms:(R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile

Chemical Property of (R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of (R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile

There total 1 articles about (R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-2-phenyl-1-((S)-1-phenylethyl)aziridine (1447034-61-8) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + acetonitrile (75-05-8,26809-02-9) → (R)-3-phenyl-4-(phenyl((S)-1-phenylethyl)amino)butanenitrile (1447034-75-4)

Guidance literature:

With cesium fluoride; In toluene; at 65 ℃; for 12h; diastereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1039/c3cc42854k

upstream raw materials:

(S)-2-phenyl-1-((S)-1-phenylethyl)aziridine

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

acetonitrile