2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine

Base Information

• Chemical Name: 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine
• CAS No.: 218912-14-2
• Molecular Formula: C₁₈H₃₀Br₂N₄OSi
• Molecular Weight: 506.356

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine

Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine

There total 10 articles about 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

{4-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,6-dibromo-phenyl}-pyrrolidin-1-yl-diazene (218912-13-1) → 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine (218912-14-2)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

methyl 3,5-dibromo-4-aminobenzoate (3282-10-8) → 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine (218912-14-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

2.1: NaNO₂; aq. HCl / acetic acid / 0.5 h / 0 °C

2.2: 75 percent / KOH; H₂O / 0.5 h / 0 °C

3.1: 88 percent / PCC / CH₂Cl₂ / 2 h / 25 °C

4.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C

5.1: AD-α; H2O / 2-methyl-propan-2-ol / 6 h / 25 °C

6.1: 88 percent / imidazole / dimethylformamide / 5 h / 0 °C

7.1: 79 percent / Ph₃P; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 2 h / 0 °C

8.1: 78 percent / Ph₃P; H₂O / tetrahydrofuran / 3 h / 60 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; AD-α; diphenylphosphoranyl azide; water; triphenylphosphine; pyridinium chlorochromate; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Reduction / 2.1: Diazotization / 2.2: Substitution / 3.1: Oxidation / 4.1: Condensation / 5.1: Addition / 6.1: Etherification / 7.1: Substitution / 8.1: Reduction;

DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine (218912-14-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 100 percent / SOCl₂ / 2 h / Heating

2.1: 98 percent / Br₂; AcOH / 0.5 h / 25 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4.1: NaNO₂; aq. HCl / acetic acid / 0.5 h / 0 °C

4.2: 75 percent / KOH; H₂O / 0.5 h / 0 °C

5.1: 88 percent / PCC / CH₂Cl₂ / 2 h / 25 °C

6.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C

7.1: AD-α; H2O / 2-methyl-propan-2-ol / 6 h / 25 °C

8.1: 88 percent / imidazole / dimethylformamide / 5 h / 0 °C

9.1: 79 percent / Ph₃P; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 2 h / 0 °C

10.1: 78 percent / Ph₃P; H₂O / tetrahydrofuran / 3 h / 60 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; AD-α; diphenylphosphoranyl azide; water; bromine; acetic acid; triphenylphosphine; pyridinium chlorochromate; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Esterification / 2.1: Bromination / 3.1: Reduction / 4.1: Diazotization / 4.2: Substitution / 5.1: Oxidation / 6.1: Condensation / 7.1: Addition / 8.1: Etherification / 9.1: Substitution / 10.1: Reduction;

DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

upstream raw materials:

{4-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,6-dibromo-phenyl}-pyrrolidin-1-yl-diazene

methyl 3,5-dibromo-4-aminobenzoate

4-amino-benzoic acid

4-methoxycarbonyl aniline

Downstream raw materials:

(R)-2-Amino-2-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethanol

tert-butoxycarbonylamino-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetic acid

{1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

(2S,3R)-2-[(R)-2-{(R)-2-tert-Butoxycarbonylamino-2-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(4-methoxy-phenyl)-acetylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 218912-14-2 2-(tert-butyl-dimethyl-silanyloxy)-1-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send