(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

Base Information

Chemical Name:(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide
CAS No.:1394073-04-1
Molecular Formula:C₂₆H₃₅N₅O₄
Molecular Weight:481.595
Hs Code.:

Synonyms:(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

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Chemical Property of (R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

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Technology Process of (R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

There total 6 articles about (R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

: 1309980-11-7
2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propan-2-ol

: 1394070-73-5
(R)-2-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

: 1394073-04-1
(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 1h; microwave irradiation;

Reference yield:

: 1268474-50-5
2-chloro-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin -6(5H)-one

: 1394073-04-1
(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 70 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / microwave irradiation

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; sodium carbonate; triethylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; water; N,N-dimethyl-formamide;

Reference yield:

: 1394070-48-4
2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

: 1394073-04-1
(R)-2-(2-(3-(2-hydroxypropan-2-yl)phenyl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 70 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / microwave irradiation

With hydrogenchloride; sodium hydride; sodium carbonate; triethylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; carbon dioxide; water; N,N-dimethyl-formamide;