1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Name:1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1374339-39-5
Molecular Formula:C₂₉H₂₂ClF₇N₄O₂
Molecular Weight:626.961
Hs Code.:

Synonyms:1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

There total 1 articles about 1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1374341-97-5
ethyl 1-[6-(5-chloro-2-{[(trifluoromethyl)sulfonyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374342-20-7
tert-butyl 4-fluoro-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate

: 1374342-19-4
1-(6-{4-chloro-4'-[1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

: 1374339-39-5
1-(6-{4-chloro-4'-[4-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 1-[6-(5-chloro-2-{[(trifluoromethyl)sulfonyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; tert-butyl 4-fluoro-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate; With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In water; acetonitrile; at 90 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; for 0.25h;

2,2,2-trifluoroethyl trifluoromethanesulphonate; Further stages;