(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

Base Information

Chemical Name:(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone
CAS No.:131414-03-4
Molecular Formula:C₂₄H₃₀O₂Si
Molecular Weight:378.587
Hs Code.:

Synonyms:(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

Suppliers and Price of (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

Chemical Property:

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Technology Process of (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

There total 1 articles about (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 116511-47-8
(-)-(2S,4S,5S)-2-<(tert-butyldiphenylsilyloxy)methyl>-5-hydroxy-4-methylcyclohexanone

: 131414-03-4
(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield: 64.0%

: 131414-03-4
(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

: 131486-90-3
(1R,3S,5S,6R)-3-<(tert-butyldiphenylsilyloxy)methyl>-5-methyl-7-oxabicyclo<4.1.0>heptan-2-one

: 131413-83-7
(1S,3S,5S,6S)-3-<(tert-butyldiphenylsilyloxy)methyl>-5-methyl-7-oxabicyclo<4.1.0>heptan-2-one

Guidance literature:: With 3,3-dimethyldioxirane; In dichloromethane; acetone; for 40h; Ambient temperature;

Reference yield:

: 131414-03-4
(4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone

: 65195-55-3
avermectin B₁a

Guidance literature:: Multi-step reaction with 27 steps

1: 64 percent / dimethyldioxirane / acetone; CH₂Cl₂ / 40 h / Ambient temperature

2: 1.) tert-BuLi / 1.) pentane, THF, -78 deg C, 10 min, 2.) -78 deg C, 10 min

3: 88 percent / oxone, pH 4 aqueous buffer / tetrahydrofuran; methanol / 3.5 h / Ambient temperature

4: 80 percent / 15percent aq. H₂SO₄ / tetrahydrofuran / 12 h / 60 °C

5: 91 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

6: 86 percent / NEt₃ / CH₂Cl₂ / 0.25 h / Ambient temperature

7: 1.) DMSO, oxalyl chloride, 2.) NEt₃ / 1.) THF, -35 deg C, 20 min, 2.) -78 deg C -> RT

8: 79 percent / NaBH₄ / methanol / Ambient temperature

9: 1.) borane methyl sulphide complex, 2.) H₂O₂, NaOH / 1.) THF, RT, 64 h, 2.) 0 deg C -> RT

10: 84 percent / toluene-p-sulphonyl chloride, pyridine / 14 h / Ambient temperature

11: 1.) tert-BuLi / 1.) hexane, THF, -78 deg C, 10 min, 2.) -78 deg C, 10 min

12: 93 percent / 80percent m-chloroperbenzoic acid (mCPBA) / CH₂Cl₂ / 0.25 h / Ambient temperature

13: 80 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / acetonitrile / 3.5 h / Ambient temperature

14: 1.) tert-BuLi / 1.) pentane, THF, -78 deg C, 10 min, 2.) -78 deg C, 1 h

15: 34 percent / 6percent Na/Hg, Na₂HPO₄ / tetrahydrofuran; methanol / 2 h / -40 °C

16: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / Heating

17: tris(triphenylphosphine)ruthenium(II) chloride / benzene; CH₂Cl₂ / 48 h / Ambient temperature

18: 32 percent / NaClO₂, 2-methylbut-2-ene / 2-methyl-propan-2-ol; H₂O / 1 h / Ambient temperature

19: 47 percent / 2-chloro-1-methylpyridinium iodide, NEt₃ / acetonitrile / 4 h / Heating

20: 61 percent / N-methylmorpholine N-oxide, tetrapropylammonium perruthenate / CH₂Cl₂ / 1 h / Ambient temperature

21: 88 percent / NEt₃ / CH₂Cl₂ / 4 h / 0 °C

22: 44 percent / CH₂Cl₂ / 2 h / -78 °C

23: 87 percent / 40percent aq. HF, pyridine / acetonitrile / 36 h / Ambient temperature

24: 1.) 2-(phenylsulphonyl)-3-(p-nitrophenylsulphonyl)oxaziridine, 2.) NaBH₄, CeCl₃ / 1.) CHCl₃, RT, 30 min, 2.) MeOH, 0 deg C, 15 min

25: 97 percent / pyridine, 4-dimethylaminopyridine (DMAP) / 1.5 h / Ambient temperature

26: 64 percent / AgClO₄, CaCO₃ / toluene / 0.17 h / Ambient temperature

27: 90 percent / LiBHEt₃ / tetrahydrofuran / -78 °C

With pyridine; 1H-imidazole; dmap; Oxone; sodium hydroxide; sodium chlorite; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; cerium(III) chloride; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; oxalyl dichloride; tris(triphenylphosphine)ruthenium(II) chloride; dimethylsulfide borane complex; 2-(phenylsulphonyl)-3-(p-nitrophenylsulphonyl)oxaziridine; pH 4 aqueous buffer; sulfuric acid; hydrogen fluoride; tetrabutyl ammonium fluoride; 2-chloro-1-methyl-pyridinium iodide; dihydrogen peroxide; tert.-butyl lithium; silver perchlorate; 3,3-dimethyldioxirane; lithium triethylborohydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;