benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

Base Information

Chemical Name:benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate
CAS No.:76525-55-8
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

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Technology Process of benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

There total 7 articles about benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 76525-56-9
9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane

: 501-53-1,94274-21-2
benzyl chloroformate

: 76525-55-8
benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

Guidance literature:: With triethylamine; In diethyl ether; for 1h; Ambient temperature;
DOI:10.1248/cpb.30.4052

Reference yield:

: 66643-50-3
(+/-)-1-(ethoxycarbonyl)-1,2,3,6-tetrahydro-3-pyridone

: 76525-55-8
benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 23 percent / cuprous chloride / tetrahydrofuran / 1 h / -50 °C

2: 69 percent / p-toluenesulfonic acid / benzene / Heating

4: 86 percent / p-toluenesulfonic acid / benzene / 20 h / Heating

5: 79 percent / KOH / H₂O; ethanol / 36 h / Heating

6: 94 percent / Et₃N / diethyl ether / 1 h / Ambient temperature

With potassium hydroxide; toluene-4-sulfonic acid; triethylamine; copper(l) chloride; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1248/cpb.30.4052

Reference yield:

: 66643-49-0
ethyl 3-hydroxy-1,2,3,6-tetrahydropiperidine-1-carboxylate

: 76525-55-8
benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: mercuric acetate / 48 h / 200 °C

2: p-toluenesulfonic acid / 1 h / Heating

3: 1.) BF₃-etherate, NaBH₄; 2.) H₂O₂, 3N NaOH / 1.) THF, ice cooling, 3 h; 2.) 2 h

4: 91 percent / pyridinium chlorochromate (PCC), NaOAc / CH₂Cl₂ / 24 h / Ambient temperature

5: 86 percent / p-toluenesulfonic acid / benzene / 20 h / Heating

6: 79 percent / KOH / H₂O; ethanol / 36 h / Heating

7: 94 percent / Et₃N / diethyl ether / 1 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; mercury(II) diacetate; dihydrogen peroxide; sodium acetate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; In diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1248/cpb.30.4052