(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Base Information

Chemical Name:(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole
CAS No.:1373357-07-3
Molecular Formula:C₄₃H₆₆N₂O₂
Molecular Weight:643.009
Hs Code.:

Synonyms:(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

There total 3 articles about (S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 62938-08-3
3,5-di-tert-butylbenzyl bromide

: 131833-90-4,152754-11-5
2,2'-methylenebis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

: 1373357-07-3
(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.202000081

Reference yield: 17.0%

: 2026-48-4,473-75-6
(S)-valinol

: 1373356-97-8
2,2-bis(3,5-di-tert-butylphenylmethyl)malononitrile

: 1373357-07-3
(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Guidance literature:: With zinc(II) chloride; In 1,2-dichloro-benzene; at 150 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.02.021

Reference yield:

: 62938-08-3
3,5-di-tert-butylbenzyl bromide

: 1373357-07-3
(S)-2-(1,3-bis(3,5-di-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: zinc(II) chloride / 1,2-dichloro-benzene / 12 h / 150 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; In N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1016/j.tetasy.2012.02.021