1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

Base Information

Chemical Name:1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide
CAS No.:1392842-95-3
Molecular Formula:C₂₇H₂₈N₄O₅S
Molecular Weight:520.609
Hs Code.:

Synonyms:1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

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Chemical Property of 1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

Chemical Property:

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Technology Process of 1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

There total 9 articles about 1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-amino-ethyl)-N-methyl-methanesulfonamide HCl salt

: 1392839-05-2
1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

: 1392842-95-3
1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

Guidance literature:: With sodium methylate; In ethanol; at 140 ℃; for 6h; microwave Irradiation;

Reference yield:

: 100-46-9
benzylamine

: 1392842-95-3
1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: N-Bromosuccinimide / dichloromethane / 3 h / Reflux

8.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

9.1: sodium methylate / ethanol / 6 h / 140 °C / microwave Irradiation

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392838-68-4
1-benzyl-3-bromo-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 1392842-95-3
1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylicacid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 3 h / Reflux

3: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

4: sodium methylate / ethanol / 6 h / 140 °C / microwave Irradiation

With N-Bromosuccinimide; sodium methylate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;