(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Base Information

Chemical Name:(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol
CAS No.:364049-64-9
Molecular Formula:C₁₁H₁₂ClF₂NO₃
Molecular Weight:279.671
Hs Code.:

Synonyms:(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Suppliers and Price of (-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

There total 2 articles about (-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-acetic acid (R)-2-benzyloxycarbonylamino-3-chloro-3,3-difluoro-1-(naphthalen-1-ylsulfanyl)-propyl ester

: 364049-64-9
(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Guidance literature:: Trifluoro-acetic acid (R)-2-benzyloxycarbonylamino-3-chloro-3,3-difluoro-1-(naphthalen-1-ylsulfanyl)-propyl ester; With potassium carbonate; In water; acetonitrile;

With sodium tetrahydroborate; In water; acetonitrile; at 20 ℃; for 0.25h; Further stages.;
DOI:10.1021/ol016087q

Reference yield:

: 364049-53-6
(-)-(2S,S_S)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropyl-1-(1-naphtyl)sulfoxide

: 364049-64-9
(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3-chloro-3,3-difluoropropanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sym-collidine / acetonitrile / 0.08 h / 0 °C

2.1: K₂CO₃ / acetonitrile; H₂O

2.2: NaBH₄ / acetonitrile; H₂O / 0.25 h / 20 °C

With 2,4,6-trimethyl-pyridine; potassium carbonate; In water; acetonitrile; 1.1: Pummerer rearrangement;
DOI:10.1021/ol016087q