2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole
• CAS No.: 1353877-24-3
• Molecular Formula: C₂₂H₁₈N₄O₄
• Molecular Weight: 402.409
• Mol file: 1353877-24-3.mol

Synonyms:2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole

Chemical Property of 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole

There total 5 articles about 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

C22H20N4O5 (1353877-18-5) → 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole (1353877-24-3)

Guidance literature:

With trichlorophosphate; at 70 - 80 ℃;

DOI:10.1016/j.saa.2011.10.021

Reference yield:

ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (938182-54-8,229015-76-3) → 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole (1353877-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / Reflux

2: triethylamine / N,N-dimethyl-formamide / 20 °C

3: trichlorophosphate / 70 - 80 °C

With hydrazine hydrate; triethylamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.saa.2011.10.021

Reference yield:

4-methyl-7-methoxy-2H-1-benzopyran-2-one (2555-28-4) → 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole (1353877-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; ammonium sulfate / acetonitrile / Reflux

2.1: potassium hydroxide / ethanol / Reflux

2.2: Reflux

3.1: triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: trichlorophosphate / 70 - 80 °C

With ammonium sulfate; N-Bromosuccinimide; triethylamine; potassium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.saa.2011.10.021

upstream raw materials:

ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate

6-methoxy-3-methyl-benzofuran-2-carbonyl chloride

5-(4-methoxyphenyl)-2H-pyrazole-3-carbohydrazide

C₂₂H₂₀N₄O₅