(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

Base Information

Chemical Name:(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone
CAS No.:1241915-08-1
Molecular Formula:C₁₆H₇ClF₄N₂O
Molecular Weight:354.691
Hs Code.:

Synonyms:(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

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Chemical Property of (4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

Chemical Property:

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Technology Process of (4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

There total 1 articles about (4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241915-07-0
(4-fluorophenyl)(4-hydroxy-7-(trifluoromethyl)quinazolin-2-yl)methanone

: 1241915-08-1
(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

Guidance literature:: With trichlorophosphate; N,N-dimethyl acetamide; at 85 ℃;

Reference yield: 16.0%

: 31230-17-8
3-methyl-5-aminopyrazole

: 1241915-08-1
(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

: 1241915-04-7
(4-fluorophenyl) (4-(5-methyl-1H-pyrazol-3-ylamino)-7-(trifluoromethyl) quinazolin-2-yl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1241915-08-1
(4-chloro-7-(trifluoromethyl)quinazolin-2-yl)(4-fluorophenyl)-methanone

: 1241915-09-2
(R,S)-(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)-7-(trifluoromethyl)quinazolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; potassium iodide; DIEA / N,N-dimethyl-formamide; acetonitrile; water

2: sodium tetrahydroborate; acetic acid / acetonitrile; water; tetrahydrofuran; methanol

With sodium tetrahydroborate; potassium iodide; DIEA; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;