{2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine

Base Information

• Chemical Name: {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine
• CAS No.: 446234-37-3
• Molecular Formula: C₁₄H₂₄N₄O₂
• Molecular Weight: 280.37
• Mol file: 446234-37-3.mol

Synonyms:{2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine

Chemical Property of {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine

There total 1 articles about {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine (446234-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

2: tetrahydrofuran; diethyl ether / -78 - 20 °C

3: aq. NaOH / ethanol / 3 h / Heating

With 4-methyl-morpholine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0200624

Reference yield:

{2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine (446234-37-3) → 6-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoic acid (5-{5-[2-(4-amino-benzenesulfonylamino)-pyrimidin-4-yl]-pentylcarbamoyl}-pentyl)-amide

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 20 °C

2: aq. NaOH / 20 °C

3: aq. HCl / 20 °C

4: diisopropylethylamine / dimethylformamide / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jf0200624

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) + {2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine (446234-37-3) → N4-acetyl{N1-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide (446234-38-4)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/jf0200624

upstream raw materials:

6-(tert-butoxycarbonylamino)hexanoic acid

Downstream raw materials:

N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide