(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

Base Information

Chemical Name:(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}
CAS No.:263024-62-0
Molecular Formula:C₄₁H₅₀N₂O₄P₂
Molecular Weight:696.807
Hs Code.:

Synonyms:(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

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Chemical Property of (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

Chemical Property:

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Technology Process of (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

There total 6 articles about (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 146476-37-1,1400149-69-0
(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine

: 88797-37-9
(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxyl dichloride

: 263024-62-0
(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

Guidance literature:: With triethylamine; In diethyl ether; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(99)01075-3

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 263024-62-0
(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

2: 80 percent / pyridine / 12 h / 0 °C

3: 95 percent / HBr / acetic acid / 1 h / 20 °C

4: 43 percent / tetrahydrofuran / 5 h / 20 °C

5: 90 percent / Et₃N / diethyl ether / -78 - 20 °C

With pyridine; hydrogen bromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetic acid; 1: Acylation / 2: Substitution / 3: Substitution / 4: Substitution / 5: Acylation;
DOI:10.1016/S0040-4020(99)01075-3

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 263024-62-0
(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

2: 95 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

3: 80 percent / pyridine / 12 h / 0 °C

4: 95 percent / HBr / acetic acid / 1 h / 20 °C

5: 43 percent / tetrahydrofuran / 5 h / 20 °C

6: 90 percent / Et₃N / diethyl ether / -78 - 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen bromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetic acid; 1: Reduction / 2: Acylation / 3: Substitution / 4: Substitution / 5: Substitution / 6: Acylation;
DOI:10.1016/S0040-4020(99)01075-3