tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate
CAS No.:1253955-13-3
Molecular Formula:C₃₃H₄₇N₃O₄Si
Molecular Weight:577.839
Hs Code.:

Synonyms:tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Suppliers and Price of tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

There total 7 articles about tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1253955-11-1
3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-((triisopropylsilyloxy)methyl)phenyl)propanamide

: 1253955-13-3
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Guidance literature:: 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-((triisopropylsilyloxy)methyl)phenyl)propanamide; With hydrazine; In methanol; Reflux;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1253955-12-2
3-amino-N-(isoquinolin-6-yl)-2-(4-((triisopropylsilyloxy)methyl)phenyl)propanamide

: 1253955-13-3
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Guidance literature:: In dichloromethane; at 0 ℃;

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1253955-13-3
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-dimethylpyridine / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water

4: 1,2-dichloro-ethane; dmap

5: hydrazine / methanol / Reflux

With 2,6-dimethylpyridine; dmap; lithium hydroxide monohydrate; 1,2-dichloro-ethane; lithium hexamethyldisilazane; hydrazine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2016.03.104