(1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

Base Information

Chemical Name:(1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate
CAS No.:1217416-74-4
Molecular Formula:C₂₀H₂₇F₃N₂O₃
Molecular Weight:400.441
Hs Code.:

Synonyms:(1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

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Chemical Property of (1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

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Technology Process of (1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

There total 1 articles about (1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556112-92-6
2-fluoro-5-trifluoromethylbenzoic acid methyl ester

: 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine

: 1217416-74-4
(1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

: 1217416-67-5
(S)-methyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

: 1217416-81-3
(S)-tert-butyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

Guidance literature:: (S)-2-hydroxymethyl-1-methylpyrrolidine; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

2-fluoro-5-trifluoromethylbenzoic acid methyl ester; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1217416-74-4
(1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

: 1217416-67-5
(S)-methyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

: 1217416-81-3
(S)-tert-butyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate

: 1215230-57-1
(S)-2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoic acid

Guidance literature:: (1-methylpyrrolidin-2-yl)methyl 2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate; (S)-methyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate; (S)-tert-butyl 2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzoate; With water; potassium hydroxide; In ethanol; at 45 ℃; for 2h;

In water; pH=5; Product distribution / selectivity; Acidic conditions;