N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide

Base Information

• Chemical Name: N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide
• CAS No.: 1429294-51-8
• Molecular Formula: C₃₄H₄₂N₈O₂
• Molecular Weight: 594.76
• Mol file: 1429294-51-8.mol

Synonyms:N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide

Chemical Property of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide

There total 14 articles about N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-methyl-piperazine (109-01-3) + 4-(3-chloropropanamido)-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)benzamide (1429294-65-4) → N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide (1429294-51-8)

Guidance literature:

In methanol; ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide (1429294-51-8)

Guidance literature:

Multi-step reaction with 9 steps

1: triethylamine / chloroform / 5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

4: tetrahydrofuran / 5 h / Reflux

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 5 h / 0 - 20 °C

7: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

8: dichloromethane / 0 - 20 °C

9: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; toluene;

DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

2-(2'-nitrophenyl)-4(3H)-quinazolinone (36567-87-0) → N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide (1429294-51-8)

Guidance literature:

Multi-step reaction with 7 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

2: tetrahydrofuran / 5 h / Reflux

3: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

4: dichloromethane / 5 h / 0 - 20 °C

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 0 - 20 °C

7: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

DOI:10.1016/j.ejmech.2013.01.051

upstream raw materials:

2-nitrobenzyl chloride

anthranilic acid amide

4-nitro-benzoyl chloride

1-methyl-piperazine