2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone

Base Information

• Chemical Name: 2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone
• CAS No.: 226990-94-9
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 226990-94-9.mol

Synonyms:2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone

Chemical Property of 2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone

There total 1 articles about 2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium phtalimide (1074-82-4) → 2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone (226990-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / dimethylformamide / 2 h / 120 °C

2: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

With magnesium; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.529

Reference yield: 70.0%

2-<2-(dimethylamino)ethyl>-3-hydroxy-3-phenylethyl-1-isoindolinone (226990-94-9) → 2-<2-(dimethylamino)ethyl>-3-<(E)-2-phenylethylidene>-1-isoindolinone

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1248/cpb.47.529

upstream raw materials:

potassium phtalimide