3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester

Base Information

• Chemical Name: 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester
• CAS No.: 936346-63-3
• Molecular Formula: C₄₆H₆₂N₆O₂₁
• Molecular Weight: 1035.03
• Mol file: 936346-63-3.mol

Synonyms:3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester

Chemical Property of 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester

There total 8 articles about 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dinitrobenoyl chloride (99-33-2) → 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester (936346-63-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 25 g / H₂ / Pd/C / methanol

3: 520 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja064515n

Reference yield:

2‐[2‐(2‐methoxyethoxy)ethoxy]ethyl 3,5‐dinitrobenzoate (93310-27-1) → 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester (936346-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 g / H₂ / Pd/C / methanol

2: 520 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja064515n

Reference yield:

(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitrobenzoylamino)-acetic acid + 2‐[2‐(2‐methoxyethoxy)ethoxy]ethyl 3,5‐diaminobenzoate (676999-10-3) → 3,5-bis-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoylamino)-acetylamino]-benzoic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester (936346-63-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 20h;

DOI:10.1021/ja064515n

upstream raw materials:

2‐[2‐(2‐methoxyethoxy)ethoxy]ethyl 3,5‐diaminobenzoate

(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitrobenzoylamino)-acetic acid methyl ester

2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-nitro-benzoic acid methyl ester

methyl 2-hydroxy-5-nitrobenzoate