methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

Base Information

Chemical Name:methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside
CAS No.:887497-36-1
Molecular Formula:C₃₄H₃₇N₉O₈
Molecular Weight:699.723
Hs Code.:

Synonyms:methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

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Chemical Property of methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

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Technology Process of methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

There total 1 articles about methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2,2,2-Trichloro-acetimidic acid (3R,4R,5R,6R)-3-azido-6-azidomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yl ester

: 274260-02-5
methyl 2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

: 887497-36-1
methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In diethyl ether; dichloromethane; at -60 - -10 ℃;
DOI:10.1039/b517725a

Reference yield:

: 887497-36-1
methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

: (2S,3R,4S,5R)-2-[(2R,3R,4R,5R,6R)-5-Amino-4-((2R,3R,4R,5R,6R)-3-amino-6-aminomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-2-aminomethyl-6-methoxy-tetrahydro-pyran-3-yloxy]-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 6 steps

1: aq. AcOH / 3 h / 80 - 85 °C

2: pyridine / 4 h / 20 °C

3: 15 mg / NaN₃ / dimethylformamide / 80 - 90 °C

4: 4 Angstroem molecular sieves; trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / -60 - -10 °C

5: 4.5 mg / CH₃ONa / aq. methanol / 20 °C / pH 12 - 13

6: pyridine; H₂ / Pd/C / 18 h

With pyridine; sodium azide; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; sodium methylate; acetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b517725a

Reference yield:

: 887497-36-1
methyl 3-O-(2',6'-diazido-3',4'-di-O-benzyl-2',6'-dideoxy-α-D-glucopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

: (2S,3R,4S,5R)-2-[(2R,3S,4R,5R,6R)-5-Amino-4-((2R,3R,4R,5R,6R)-3-amino-6-aminomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy]-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: aq. AcOH / 3 h / 80 - 85 °C

2: 31 mg / pyridine / 2 h / 20 °C

3: 4 Angstroem molecular sieves; trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / -60 - -10 °C

4: 7.0 mg / CH₃ONa / aq. methanol / 20 °C / pH 12 - 13

5: pyridine; H₂ / Pd/C / 18 h

With pyridine; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; sodium methylate; acetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/b517725a