(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

Base Information

Chemical Name:(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane
CAS No.:939027-89-1
Molecular Formula:C₂₃H₂₅ClN₂O₅S
Molecular Weight:476.981
Hs Code.:

Synonyms:(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

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Chemical Property of (2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

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Technology Process of (2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

There total 4 articles about (2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 50765-70-3
(S)-1-tosyloxy-2,3-propanediol

: 82362-50-3
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone

: 939027-89-1
(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

Guidance literature:: (S)-1-tosyloxy-2,3-propanediol; 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone; With methanesulfonic acid; In dichloromethane; at 20 ℃; for 24h; Heating / reflux;

With water; potassium carbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 143327-55-3
1-bromo-4-(4-chlorophenyl)butan-2-one

: 939027-89-1
(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 0 - 20 °C

2.1: methanesulfonic acid / dichloromethane / 24 h / 20 °C / Heating / reflux

2.2: 20 °C

With methanesulfonic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3506-75-0
4-(4-chlorophenyl)butan-2-one

: 939027-89-1
(2SR,4S)-2-(1-imidazolylmethyl)-2-(2-(4-chlorophenyl)ethyl)-4-(4-methylbenzenesulfonyloxy-methyl)-1,3-dioxalane

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / methanol / 1.33 h / 7 - 10 °C

2.1: N,N-dimethyl-formamide / 0 - 20 °C

3.1: methanesulfonic acid / dichloromethane / 24 h / 20 °C / Heating / reflux

3.2: 20 °C

With methanesulfonic acid; bromine; In methanol; dichloromethane; N,N-dimethyl-formamide;