N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide

Base Information

• Chemical Name: N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide
• CAS No.: 102754-41-6
• Molecular Formula: C₂₄H₂₀N₂O₃
• Molecular Weight: 384.434
• Mol file: 102754-41-6.mol

Synonyms:N-Benzyl-2-<5-(benzyloxy)-3-indolyl>glyoxylamid

Chemical Property of N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide

Chemical Property:

• Melting Point: 203-205°C
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide is Serotonin (S274980) derivative. Used in the synthesis of manzamine C, infractine and 6-hydroxyinfractine.

Technology Process of N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide

There total 2 articles about N,5-Dibenzyl-5-hydroxy-indole-3-glyoxylaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyloxy-1H-indole (1215-59-4) → N-Benzyl-2-<5-(benzyloxy)-3-indolyl>glyoxylamid (102754-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 2 h / Ambient temperature

2: H₂O / 3 h

In diethyl ether; water;

Reference yield:

2-[5-(benzyloxy)-1H-indol-3-yl]-2-oxoacetyl chloride (22424-61-9) + benzylamine (100-46-9) → N-Benzyl-2-<5-(benzyloxy)-3-indolyl>glyoxylamid (102754-41-6)

Guidance literature:

In water; for 3h; Yield given;

Reference yield: 96.0%

N-Benzyl-2-<5-(benzyloxy)-3-indolyl>glyoxylamid (102754-41-6) → N-Benzyl-2-<5-(benzyloxy)-3-indolyl>-1-ethanamin (147918-24-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 120h; Heating;

upstream raw materials:

2-[5-(benzyloxy)-1H-indol-3-yl]-2-oxoacetyl chloride

benzylamine

5-benzyloxy-1H-indole

Downstream raw materials:

N-Benzyl-2-<5-(benzyloxy)-3-indolyl>-1-ethanamin

6-Benzyloxy-1-(2-<(2,4,10-Trioxatricyclo<3.3.1.1^3,7>dec-3-yl)ethyl>)-9H-pyrido<3,4-b>indol

2-Benzyl-6-(benzyloxy)-1-(2-<(2,4,10-trioxatricyclo<3.3.1.1^3,7>dec-3-yl)ethyl>)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

Refernces