1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane

Base Information

• Chemical Name: 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane
• CAS No.: 945413-19-4
• Molecular Formula: C₂₆H₃₁N₃O₄
• Molecular Weight: 449.55
• Mol file: 945413-19-4.mol

Synonyms:1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane

Chemical Property of 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane

There total 9 articles about 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)hept-6-yne (945413-48-9) → 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane (945413-19-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 25 ℃; for 40h;

DOI:10.1021/jm061414r

Reference yield:

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]hept-6-yne (808134-52-3) → 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane (945413-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PdCl₂(PPh₃)2 / tetrahydrofuran / 0.08 h / 25 °C

1.2: Et₃N / CuI / tetrahydrofuran / 0.58 h / 25 °C

1.3: 40 percent / tetrahydrofuran / 14 h / 25 °C

2.1: 55 percent / H₂ / Pd/C / tetrahydrofuran; methanol / 40 h / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm061414r

Reference yield:

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(trimethylsilyl)hept-6-yne (808134-53-4) → 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)-heptane (945413-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 77 percent / Bu₄NF / tetrahydrofuran / 0.58 h / 0 °C

2.1: PdCl₂(PPh₃)2 / tetrahydrofuran / 0.08 h / 25 °C

2.2: Et₃N / CuI / tetrahydrofuran / 0.58 h / 25 °C

2.3: 40 percent / tetrahydrofuran / 14 h / 25 °C

3.1: 55 percent / H₂ / Pd/C / tetrahydrofuran; methanol / 40 h / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm061414r

upstream raw materials:

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(3-(tert-butyloxycarbonyl)aminophenyl)hept-6-yne

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]hept-6-yne

1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(trimethylsilyl)hept-6-yne

pyridine-2-carbaldehyde