5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:481049-97-2
Molecular Formula:C₄₄H₃₉F₂N₅O₆S
Molecular Weight:803.886
Hs Code.:

5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Synonyms:5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 10 articles about 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 481049-97-2
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

2.1: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

3.1: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

4.1: 87 percent / HCl; HCO₂H / 10 percent Pd/C/water / diethyl ether / 3.5 h / 20 °C / atmospheric pressure

5.1: Et₃N / CH₂Cl₂ / 20 °C

5.2: CH₂Cl₂ / 20 °C

With hydrogenchloride; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C/water; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jm020180i

Reference yield:

: 530-62-1
1,1'-carbonyldiimidazole

: 216067-66-2
O-(2,4-dimethoxy-benzyl)-hydroxylamine

: 174072-63-0
6-(4-aminophenyl)-5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 481049-97-2
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 1,1'-carbonyldiimidazole; 6-(4-aminophenyl)-5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; With triethylamine; In dichloromethane; at 20 ℃;

O-(2,4-dimethoxy-benzyl)-hydroxylamine; In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1021/jm020180i

Reference yield:

: 5332-96-7
1-(4-nitrophenyl)propan-2-one

: 481049-97-2
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 67 percent / sulfur / ethanol / 2 h / 65 °C

2.1: pyridine / 2 h / 45 °C

3.1: 50.4 g / NaOMe / methanol / 6 h / 20 °C

4.1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

5.1: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

6.1: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

7.1: 87 percent / HCl; HCO₂H / 10 percent Pd/C/water / diethyl ether / 3.5 h / 20 °C / atmospheric pressure

8.1: Et₃N / CH₂Cl₂ / 20 °C

8.2: CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); ammonium acetate; sodium methylate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C/water; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm020180i