N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Base Information

Chemical Name:N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine
CAS No.:710971-46-3
Molecular Formula:C₁₇H₂₄F₄N₂
Molecular Weight:332.385
Hs Code.:

Synonyms:N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Chemical Property:

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Technology Process of N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

There total 3 articles about N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 710971-52-1
4-[(4-fluoro-2-trifluoromethyl-benzyl)-isobutyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

: 710971-46-3
N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 710971-46-3
N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: Na(AcO)3BH / 1,2-dichloro-ethane; dimethylformamide

3: TFA / CH₂Cl₂

With hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 179556-97-9
tert-butyl 4-[(2-methylpropyl)amino]piperidine-1-carboxylate

: 710971-46-3
N-(2-methylpropyl)-N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: Na(AcO)3BH / 1,2-dichloro-ethane; dimethylformamide

2: TFA / CH₂Cl₂

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.02.008