tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

Base Information

Chemical Name:tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate
CAS No.:1300025-12-0
Molecular Formula:C₆₁H₇₁N₅O₁₀
Molecular Weight:1034.26
Hs Code.:

Synonyms:tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

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Chemical Property of tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

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Technology Process of tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

There total 6 articles about tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1300025-11-9
4-(3-(tert-butoxycarbonylamino)propylamino)-4-oxobutanoic acid

: 74272-81-4
2,3-bis(benzyloxy)-N-(3-(4-(2,3-bis(benzyloxy)benzamido)butylamino)propyl)benzamide

: 1300025-12-0
tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1039/c0ob00846j

Reference yield:

: 303-38-8
2,3-Dihydroxybenzoic acid

: 1300025-12-0
tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 23 °C / Reflux; Inert atmosphere

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere

3.1: water; potassium hydroxide / tetrahydrofuran / 10 h / 23 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.5 h / 23 °C / Inert atmosphere

4.2: 14 h / Inert atmosphere

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C / Cooling with ice; Inert atmosphere

With thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium iodide; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00846j

Reference yield:

: 2411-83-8
methyl-2,3-dihydroxybenzoate

: 1300025-12-0
tert-butyl-3-(4-((4-(2,3-bis(benzyloxy)benzamido)butyl)(3-(2-,3-bis(benzyloxy)benzamido)propyl)amino)-4-oxobutanamido)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere

2.1: water; potassium hydroxide / tetrahydrofuran / 10 h / 23 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.5 h / 23 °C / Inert atmosphere

3.2: 14 h / Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C / Cooling with ice; Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium iodide; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00846j