C₄₄H₆₆O₈SSi₂

Base Information

• Chemical Name: C₄₄H₆₆O₈SSi₂
• CAS No.: 86668-65-7
• Molecular Formula: C₄₄H₆₆O₈SSi₂
• Molecular Weight: 811.24
• Mol file: 86668-65-7.mol

Synonyms:C₄₄H₆₆O₈SSi₂

Chemical Property of C₄₄H₆₆O₈SSi₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₆₆O₈SSi₂

There total 12 articles about C₄₄H₆₆O₈SSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C46H68O9SSi2 (86668-64-6) → C44H66O8SSi2 (86668-65-7)

Guidance literature:

With methyllithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Yield given;

DOI:10.1021/jo00167a020

Reference yield:

8-hydroxy-1-acetoxy-1(R*),4,4a(S*),9a(S*)-tetrahydroanthraquinone (86668-63-5) → C44H66O8SSi2 (86668-65-7)

Guidance literature:

Multi-step reaction with 10 steps

1: NaBH₄ / toluene; methanol / 0.12 h / 5 °C

2: 84 percent / 1-hydroxybenzotriazole, Et₃N / acetonitrile / 0.5 h / 65 °C / var. silyl transfer agents, without Et₃N, var. solv., var. temp., var. time

3: 59 percent / LiBH₄ / tetrahydrofuran / 48 h / 0 °C

4: 86 percent / imidazole / dimethylformamide / 6 h / 50 °C

5: 91 percent / diisobutylaluminum hydride / toluene; hexane / 0.5 h / -62 °C

6: 82 percent / Ac₂O / toluene / 20 h / 25 °C

7: 83 percent / 1 M BCl₃ / CH₂Cl₂ / 1.) 1 h, -15 deg C, 2.) 2 h, 0 deg C

8: 1.) 3 Angstroem molecular sieves, 2.) camphorsulfonic acid / 1.) reflux, 1 h; 2.) reflux, 5 h

9: m-chloroperbenzoic acid / CH₂Cl₂ / 0.25 h / -78 °C

10: CH₃Li / tetrahydrofuran / 0.08 h / -78 °C

With 1H-imidazole; sodium tetrahydroborate; lithium borohydride; 3 A molecular sieve; camphor-10-sulfonic acid; methyllithium; acetic anhydride; boron trichloride; diisobutylaluminium hydride; benzotriazol-1-ol; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/jo00167a020

Reference yield:

2-acetoxy-3-(4'-methoxyphenylthio)-1,3-butadiene (65174-13-2) → C44H66O8SSi2 (86668-65-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / 1 M BCl₃ / CH₂Cl₂ / 1.) 1 h, -15 deg C, 2.) 2 h, 0 deg C

2: 1.) 3 Angstroem molecular sieves, 2.) camphorsulfonic acid / 1.) reflux, 1 h; 2.) reflux, 5 h

3: m-chloroperbenzoic acid / CH₂Cl₂ / 0.25 h / -78 °C

4: CH₃Li / tetrahydrofuran / 0.08 h / -78 °C

With 3 A molecular sieve; camphor-10-sulfonic acid; methyllithium; boron trichloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00167a020

upstream raw materials:

C₄₆H₆₈O₉SSi₂

8-hydroxy-1-acetoxy-1(R*),4,4a(S*),9a(S*)-tetrahydroanthraquinone

2-acetoxy-3-(4'-methoxyphenylthio)-1,3-butadiene

8,9-dihydroxy-1-acetoxy-10-oxo-1(R*),4,4a(S*),9(R*),9a(R*),10-hexahydroanthracene