[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

Base Information

Chemical Name:[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester
CAS No.:280765-84-6
Molecular Formula:C₃₉H₅₈N₂O₈
Molecular Weight:682.898
Hs Code.:

Synonyms:[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

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Chemical Property of [3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

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Technology Process of [3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

There total 5 articles about [3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 75857-94-2
(5S)-N-(benzyloxycarbonyl)-5-methoxycarbonyl-2-pyrrolidinone

: (3β,5β,12α)-3-amino-12-hydroxycholan-24-oic acid methyl ester

: 280765-84-6
[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

Guidance literature:: In 1,4-dioxane; at 50 - 95 ℃; for 53h;
DOI:10.1021/op900008a

Reference yield:

: 3245-38-3
methyl deoxycholate

: 280765-84-6
[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

2: hydrogenchloride / methanol

4: 1,4-dioxane / 53 h / 50 - 105 °C

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; 1: Mitsunobu reaction;

Reference yield:

: 32159-21-0
Cbz-L-pGlu-OH

: 280765-84-6
[3β(S),5β,12α]-3-[[5-methoxy-1,5-dioxo-4-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-12-hydroxycholan-24-oic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6.5 h / Heating / reflux

2: 1,4-dioxane / 53 h / 50 - 105 °C

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;