1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Base Information

Chemical Name:1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide
CAS No.:1574116-76-9
Molecular Formula:C₂₆H₂₈ClF₃N₂O₃S
Molecular Weight:541.034
Hs Code.:

Synonyms:1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Chemical Property of 1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Technology Process of 1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

There total 10 articles about 1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574118-76-5
1-benzyl-4-bromo-3-(4-chlorophenyl)-N-(2,2-dimethylpropyl)-N-methyl-5-(trifluoromethyl)pyrrole-2-carboxamide

: 20277-69-4
sodium methansulfinate

: 1574116-76-9
1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: With copper(I) trifluoromethanesulfonate benzene; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 140 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1574110-26-1
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

: 1574116-76-9
1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / acetic acid / 10 - 20 °C

2: N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene / dimethyl sulfoxide / 18 h / 140 °C / Inert atmosphere

With copper(I) trifluoromethanesulfonate benzene; bromine; N,N`-dimethylethylenediamine; In acetic acid; dimethyl sulfoxide;

Reference yield:

: 1-chloro-4-(1-iodo-2-tosylethyl)benzene

: 1574116-76-9
1-benzyl-3-(4-chlorophenyl )-N-(2,2-dimethyl-propyl)-N-methyl-4-methylsulfonyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / acetonitrile / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere; Cooling

3.2: 24 h

4.1: sodium hydroxide; methanol / tetrahydrofuran; water / 18 h / Reflux

5.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

6.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.18 h

7.1: bromine / acetic acid / 10 - 20 °C

8.1: N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene / dimethyl sulfoxide / 18 h / 140 °C / Inert atmosphere

With methanol; ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; copper(I) trifluoromethanesulfonate benzene; bromine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; N,N`-dimethylethylenediamine; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;