Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

Base Information

Chemical Name:Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester
CAS No.:167645-07-0
Molecular Formula:C₂₀H₁₇FN₂O₃
Molecular Weight:352.365
Hs Code.:

Synonyms:Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

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Chemical Property of Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

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Technology Process of Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

There total 5 articles about Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 108-24-7
acetic anhydride

: 167645-03-6
1-(2-Fluoro-phenyl)-6-methyl-2-oxy-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

: 167645-07-0
Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

Guidance literature:: at 105 ℃; for 10h;
DOI:10.1248/cpb.42.2071

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 167645-07-0
Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BCl₃, AlCl₃, 2.) 2N aq. HCl / 1.) toluene, reflux, 16 h, 2.) toluene, reflux, 2.5 h

2: 93.8 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 98.8 percent / 50percent aq. NaOH, NH₂OH*HCl / ethanol / 2.5 h / 50 - 55 °C

4: 75 percent / 10 h / 105 °C

With pyridine; hydrogenchloride; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; boron trichloride; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.2071

Reference yield:

: 167645-01-4
(2-Fluoro-phenyl)-(2-methyl-2,3-dihydro-1H-indol-7-yl)-methanone

: 167645-07-0
Acetic acid 1-(2-fluoro-phenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93.8 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 98.8 percent / 50percent aq. NaOH, NH₂OH*HCl / ethanol / 2.5 h / 50 - 55 °C

3: 75 percent / 10 h / 105 °C

With pyridine; sodium hydroxide; hydroxylamine hydrochloride; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.2071