(2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene

Base Information

• Chemical Name: (2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene
• CAS No.: 1417913-09-7
• Molecular Formula: C₁₅H₁₆F₄O₂
• Molecular Weight: 304.284
• Mol file: 1417913-09-7.mol

Synonyms:(2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene

Chemical Property of (2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene

There total 1 articles about (2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-3,7-dimethylocta-2,6-diene (5389-87-7) → (2R,4aR)-2-fluoro-4a-methyl-7-(trifluoromethoxy)-2,3,4,4a,9,9a-hexahydro-1H-xanthene (1417913-09-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / diethyl ether; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 16 h / 40 °C / Inert atmosphere

2.1: chloroform / 0.5 h / 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

4.1: sodium periodate; hydrogenchloride / water; tetrahydrofuran / 2 h / 20 °C

5.1: tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

6.1: silver tetrafluoroborate; Pentafluorobenzonitrile; xenon fluoride; C₄₈H₅₀I₂P₂Pt; Trimethylmethoxysilane / 24 h / 0 °C / Cooling with liquid nitrogen

With hydrogenchloride; sodium periodate; silver tetrafluoroborate; xenon fluoride; Trimethylmethoxysilane; Pentafluorobenzonitrile; C₄₈H₅₀I₂P₂Pt; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; mineral oil;

DOI:10.1021/ja3116795

upstream raw materials:

1-chloro-3,7-dimethylocta-2,6-diene