17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one

Base Information

• Chemical Name: 17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one
• CAS No.: 304432-40-4
• Molecular Formula: C₂₇H₃₂O₃
• Molecular Weight: 404.549
• Mol file: 304432-40-4.mol

Synonyms:17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one

Chemical Property of 17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one

There total 1 articles about 17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

propargyl alcohol (107-19-7) + 11β-phenylestr-4-ene-3,17-dione → 17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one (304432-40-4)

Guidance literature:

11β-phenylestr-4-ene-3,17-dione; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

propargyl alcohol; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00602-5

Reference yield: 98.0%

17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one (304432-40-4) → (Z)-17β-hydroxy-17α-(3-hydroxyprop-1-enyl)-11β-phenylestr-4-en-3-one (304432-41-5)

Guidance literature:

With pyridine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00602-5

Reference yield:

17β-hydroxy-17α-(3-hydroxyprop-1-ynyl)-11β-phenyl-estr-4-en-3-one (304432-40-4) → 11β-phenylspiro[estr-4-ene-17β,2'(5'H)-furan]-3,5'-dione (304432-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine; H₂ / palladium on calcium carbonate / tetrahydrofuran / 0.5 h / 20 °C

2: 69 percent / silver carbonate on Celite / toluene / 3 h / Heating

With pyridine; hydrogen; silver carbonate; palladium on activated charcoal; In tetrahydrofuran; toluene; 1: Catalytic hydrogenation / 2: Cyclization;

DOI:10.1016/S0040-4020(00)00602-5

upstream raw materials:

propargyl alcohol

Downstream raw materials:

(Z)-17β-hydroxy-17α-(3-hydroxyprop-1-enyl)-11β-phenylestr-4-en-3-one

11β-phenylspiro[estr-4-ene-17β,2'(5'H)-furan]-3,5'-dione

11β-(4-nitrophenyl)spiro[estr-4-ene-17β,2'(5'H)-furan]-3,5'-dione