4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid
CAS No.:1256373-91-7
Molecular Formula:C₁₈H₈ClF₂NO₂S
Molecular Weight:375.783
Hs Code.:

Synonyms:4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

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Chemical Property of 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

Chemical Property:

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Technology Process of 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

There total 7 articles about 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232069-37-2
ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylate

: 1256373-91-7
4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

Guidance literature:: ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 2810-04-0
Ethyl thiophene-2-carboxylate

: 1256373-91-7
4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 60 °C

2: caesium carbonate / palladium diacetate; XPhos / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; bromine; caesium carbonate; acetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 935685-88-4
3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarbonitrile

: 1256373-91-7
4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; XPhos / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; caesium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1,2-dimethoxyethane; water;