6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

Base Information

Chemical Name:6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide
CAS No.:76845-21-1
Molecular Formula:C₁₇H₁₇ClN₂O₅S
Molecular Weight:396.851
Hs Code.:

Synonyms:6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

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Chemical Property of 6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

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Technology Process of 6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

There total 9 articles about 6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 76845-27-7
7-chloro-6-sulfamoyl-2,3-dihydro-1,4-benzodioxin-3-carboxylic acid

: 87-62-7
2,6-dimethylaniline

: 76845-21-1
6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

Guidance literature:: With phosphorus trichloride; In chlorobenzene; at 100 - 130 ℃;

Reference yield:

: 100-44-7
benzyl chloride

: 76845-21-1
6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 9 steps

1: 77.4 percent / NaH / dimethylformamide / 1.) r.t., 30 min, 2.) 50-60 deg C, 45 min

2: 3.809 g / NaH / dimethylformamide / 5 h / 76 °C

3: 82.7 percent / conc. HCl / 1 h / 110 - 115 °C

4: 89.6 percent / KOH / ethanol / 0.33 h / Heating

5: 80 percent / metallic iron, conc. HCl / methanol / 10 h / Heating

6: 1.) NaNO₂, AcOH, conc. HCl, 2.) CuCl₂*2H₂O, 33percent SO₂-AcOH / 1.) H₂O, -15 - -5 deg C, 35 min, 2.) H₂O, 33 deg C, 50 min

7: conc. NH₄OH / acetone / 0.5 h / Heating

8: 78 percent / KOH, KMnO₄ / H₂O / 0 °C

9: 74 percent / PCl₃ / chlorobenzene / 100 - 130 °C

With hydrogenchloride; potassium hydroxide; ammonium hydroxide; potassium permanganate; sulfur dioxide; iron; sodium hydride; acetic acid; sodium nitrite; phosphorus trichloride; In methanol; ethanol; water; N,N-dimethyl-formamide; chlorobenzene; acetone;

Reference yield:

: 120589-21-1
6-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-3-ylmethanol

: 76845-21-1
6-Chloro-7-sulfamoyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂, AcOH, conc. HCl, 2.) CuCl₂*2H₂O, 33percent SO₂-AcOH / 1.) H₂O, -15 - -5 deg C, 35 min, 2.) H₂O, 33 deg C, 50 min

2: conc. NH₄OH / acetone / 0.5 h / Heating

3: 78 percent / KOH, KMnO₄ / H₂O / 0 °C

4: 74 percent / PCl₃ / chlorobenzene / 100 - 130 °C

With hydrogenchloride; potassium hydroxide; ammonium hydroxide; potassium permanganate; sulfur dioxide; acetic acid; sodium nitrite; phosphorus trichloride; In water; chlorobenzene; acetone;