N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide
CAS No.:126170-63-6
Molecular Formula:C₂₂H₂₉N₅O₄Si
Molecular Weight:455.589
Hs Code.:

Synonyms:N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

There total 6 articles about N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126170-64-7
N-{9-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-oxo-oxetan-2-yl]-9H-purin-6-yl}-benzamide

: 126170-63-6
N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

: 136780-31-9
N-{9-[(2R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Yield given. Yields of byproduct given;
DOI:10.1016/0040-4039(91)80825-Q

Reference yield:

: 121885-21-0
Oxetanocin A N⁶-benzoate

: 126170-63-6
N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent / imidazole / dimethylformamide

2: 75 percent / pyridine

3: 72 percent / t-BuOK / acetone / 1 h / 0 °C

4: HIO₄, KMnO₄

5: NaBH₄ / methanol / 1 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; potassium permanganate; potassium tert-butylate; periodic acid; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4039(91)80825-Q

Reference yield:

: 126170-62-5
N-{9-[(2R,4S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methylene-oxetan-2-yl]-9H-purin-6-yl}-benzamide

: 126170-63-6
N-{9-[(2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-oxetan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: HIO₄, KMnO₄

2: NaBH₄ / methanol / 1 h / 0 °C

With sodium tetrahydroborate; potassium permanganate; periodic acid; In methanol;
DOI:10.1016/0040-4039(91)80825-Q