N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

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Chemical Name:N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide
CAS No.:1205748-13-5
Molecular Formula:C₄₂H₄₄ClN₇O₅S₂
Molecular Weight:826.44
Hs Code.:

N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

Synonyms:N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

Suppliers and Price of N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

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Chemical Property of N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

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Technology Process of N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

There total 14 articles about N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 406233-35-0
4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide

: 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido-[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylic acid tris(trifluoroacetate)

: 1205748-13-5
N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

Guidance literature:: 4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide; 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido-[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylic acid tris(trifluoroacetate); With dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 144h;

With water; ammonium chloride; In dichloromethane;

Reference yield:

: 23056-33-9
2-chloro-4-methyl-5-nitro-pyridine

: 1205748-13-5
N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: methanol / 5 h / Reflux

2.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h

2.2: Reflux

2.3: 2 h / 20 °C

3.1: hydrogen / palladium on carbon / ethanol / 24 h

4.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.2: 24 h

5.1: hydrogenchloride / ethanol / 8 h / Reflux

6.1: phosphorus pentachloride / tetrahydrofuran / 2 h / 0 °C

6.2: 12 h / 20 °C

6.3: 10 h / Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

7.2: 17 h

8.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 6 h / Reflux

8.2: 6 h / 0 - 20 °C

9.1: hydrogen bromide / acetic acid / 3 h / Reflux

9.2: 0 - 20 °C

9.3: 16 h / 0 - 20 °C

10.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 18 h / 65 °C

11.1: hydrogenchloride / 20 wt% Pd(OH)2/C / methanol / 16 h

12.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 50 °C

13.1: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

13.2: 2 h / 20 °C

13.3: Oasis cartridge

14.1: dmap; N-ethyl-N,N-diisopropylamine / 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h / 20 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; phosphorus pentachloride; potassium tert-butylate; hydrogen bromide; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium on carbon; 20 wt% Pd(OH)2/C; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3469-62-3
ethyl 3-(2-methoxy-5-nitropyridin-4-yl)-2-oxopropanoate

: 1205748-13-5
N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogen / palladium on carbon / ethanol / 24 h

2.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

2.2: 24 h

3.1: hydrogenchloride / ethanol / 8 h / Reflux

4.1: phosphorus pentachloride / tetrahydrofuran / 2 h / 0 °C

4.2: 12 h / 20 °C

4.3: 10 h / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

5.2: 17 h

6.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 6 h / Reflux

6.2: 6 h / 0 - 20 °C

7.1: hydrogen bromide / acetic acid / 3 h / Reflux

7.2: 0 - 20 °C

7.3: 16 h / 0 - 20 °C

8.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 18 h / 65 °C

9.1: hydrogenchloride / 20 wt% Pd(OH)2/C / methanol / 16 h

10.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 50 °C

11.1: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

11.2: 2 h / 20 °C

11.3: Oasis cartridge

12.1: dmap; N-ethyl-N,N-diisopropylamine / 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h / 20 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; phosphorus pentachloride; hydrogen bromide; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium on carbon; 20 wt% Pd(OH)2/C; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;