((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

Base Information

Chemical Name:((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate
CAS No.:1567347-22-1
Molecular Formula:C₃₂H₃₇ClF₂N₃O₇PS
Molecular Weight:712.151
Hs Code.:

Synonyms:((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

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Chemical Property of ((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

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Technology Process of ((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

There total 2 articles about ((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.2%

: 1029872-54-5,918504-65-1
vemurafenib

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1567347-22-1
((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

Guidance literature:: vemurafenib; With potassium hydroxide; In N,N-dimethyl-formamide; at 10 ℃; for 0.333333h;

di-tert-butyl chloromethyl phosphate; In N,N-dimethyl-formamide; at 10 ℃; for 16.5h;

Reference yield:

: 33494-80-3
potassium di-tert-butylphosphate

: 1567347-22-1
((5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl) di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 0.17 h / 0 °C

1.2: 20 h / 20 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 10 °C

2.2: 16 h / 10 °C

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; potassium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide;