tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

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Chemical Name:tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate
CAS No.:1201640-47-2
Molecular Formula:C₃₄H₄₆BrN₃O₇
Molecular Weight:688.659
Hs Code.:

Synonyms:tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

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Chemical Property of tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

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Technology Process of tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

There total 14 articles about tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201640-46-1
3-(3-bromophenethoxy)-N-cyclohexyl-N-(2-oxoethyl)propanamide

: 8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

: 1201640-47-2
tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

: C₃₉H₅₄BrN₃O₉

Guidance literature:: 3-(3-bromophenethoxy)-N-cyclohexyl-N-(2-oxoethyl)propanamide; 8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride; With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water; for 0.0833333h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; water;

di-tert-butyl dicarbonate; With triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 89684-58-2
1-(2,4-dihydroxy-3-nitrophenyl)ethanone

: 1201640-47-2
tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

: C₃₉H₅₄BrN₃O₉

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / acetonitrile / 60 °C / Reflux

2.1: acetic acid; zinc / 20 - 40 °C / Cooling with ice

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

3.2: 20 h / 100 °C

4.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

5.1: sodium azide / N,N-dimethyl-formamide / 2 h

6.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

7.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 0.08 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; zinc; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 871101-87-0
1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone

: 1201640-47-2
tert-butyl 2-(3-(3-bromophenethoxy)-N-cyclohexylpropanamido)ethyl(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate

: C₃₉H₅₄BrN₃O₉

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

1.2: 20 h / 100 °C

2.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 2 h

4.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

5.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 0.08 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;