di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

Base Information

Chemical Name:di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate
CAS No.:1331825-33-2
Molecular Formula:C₁₇H₃₂N₂O₆
Molecular Weight:360.451
Hs Code.:

Synonyms:di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

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Technology Process of di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

There total 3 articles about di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1350321-41-3
C₇H₁₂N₆O₂

: 1331825-33-2
di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.06.084

Reference yield:

: 1350321-46-8
C₉H₁₆N₆O₃

: 1331825-33-2
di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 1 h / Reflux

2: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 12 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; In methanol;
DOI:10.1016/j.bmcl.2011.06.084

Reference yield:

: 1223053-81-3
(1R,2R,4S,5S)-2,4-diazido-5-(methoxymethoxy)cyclohex-anol

: 1331825-33-2
di-tert-butyl ((1R,3S,4S,6R)-4-hydroxy-6-methoxycyclohexane-1,3-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; water / methanol / 1 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 12 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; sodium hydride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.084