methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Base Information

Chemical Name:methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate
CAS No.:1572290-86-8
Molecular Formula:C₂₀H₂₀O₅
Molecular Weight:340.376
Hs Code.:

Synonyms:methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Chemical Property of methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Technology Process of methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

There total 4 articles about methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 144619-97-6
5-benzyloxy-6-methoxy-1-tetralone

: 616-38-6
carbonic acid dimethyl ester

: 1572290-86-8
methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; Reflux;
DOI:10.1021/acs.joc.0c01462

Reference yield:

: 366017-84-7
5-hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1572290-86-8
methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: sodium hydride / tetrahydrofuran / Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.0c01462

Reference yield:

: 26231-23-2
5-Bromo-6-methoxy-3,4-dihydro-2H-napthalen-1-one

: 1572290-86-8
methyl 5-(benzyloxy)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos / water; 1,4-dioxane / 14 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: sodium hydride / tetrahydrofuran / Reflux

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium hydride; potassium carbonate; potassium hydroxide; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.0c01462