(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Base Information

Chemical Name:(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine
CAS No.:1403396-04-2
Molecular Formula:C₂₃H₃₄ClN₃OSSi
Molecular Weight:464.147
Hs Code.:

Synonyms:(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

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Chemical Property of (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

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Technology Process of (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

There total 3 articles about (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 633317-81-4
1-(4-chlorophenyl)cyclopropanecarbohydrazide

: 1403396-03-1
(7R)-7-({[tert-butyl(dimethyl)silyl]oxy}methyl)-7-methyl-5-methylthio-2,3,6,7-tetrahydro-1,4-thiazepine

: 1403396-04-2
(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Guidance literature:: In butan-1-ol; at 140 ℃; for 6h; Inert atmosphere;

Reference yield:

: C₁₅H₁₉ClN₂O₃

: 1403396-04-2
(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

2: butan-1-ol / 6 h / 140 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; methanol; butan-1-ol;

Reference yield:

: 72934-37-3
3-(4-chlorophenyl)-1-cyclopropanecarboxylic acid

: 1403396-04-2
(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(4-chlorophenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; t-butoxycarbonylhydrazine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

3: butan-1-ol / 6 h / 140 °C / Inert atmosphere

With hydrogenchloride; t-butoxycarbonylhydrazine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; butan-1-ol;