(S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide

Base Information

• Chemical Name: (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide
• CAS No.: 85239-47-0
• Molecular Formula: C₁₉H₁₆N₂O₂*HI
• Molecular Weight: 432.261
• Mol file: 85239-47-0.mol

Synonyms:(S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide

Chemical Property of (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide

There total 2 articles about (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-3-(1H-Indol-3-yl)-2-thiobenzoylamino-propionic acid methyl ester (85239-37-8) → (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide (85239-47-0)

Guidance literature:

With methyl iodide; In dichloromethane; for 24h; Heating;

DOI:10.1248/cpb.33.3237

Reference yield:

N-benzoyl-L-tryptophan methyl ester (2717-75-1) → (S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide (85239-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Lawesson's reagent

2: 100 percent / CH₃I / CH₂Cl₂ / 24 h / Heating

With Lawessons reagent; methyl iodide; In dichloromethane;

DOI:10.1248/cpb.33.3237

Reference yield:

(S)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide (85239-47-0) → (1S,3S)-methyl 1-phenyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate (91200-21-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -78 ℃; for 1h; Yield given;

DOI:10.1248/cpb.33.3237

upstream raw materials:

(S)-3-(1H-Indol-3-yl)-2-thiobenzoylamino-propionic acid methyl ester

N-benzoyl-L-tryptophan methyl ester

Downstream raw materials:

(1S,3S)-methyl 1-phenyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate