(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Base Information

Chemical Name:(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate
CAS No.:1380299-33-1
Molecular Formula:C₃₁H₂₉F₃N₂O₅S
Molecular Weight:598.643
Hs Code.:

(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Synonyms:(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Chemical Property of (3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Technology Process of (3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

There total 2 articles about (3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 91-44-1,61968-71-6
7-diethylamino-4-methylcoumarin

: 1293894-60-6
(3R)-7-bromomethyl-5-oxo-8-(3-trifluoromethyl-phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

: 1380299-33-1
(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: 7-diethylamino-4-methylcoumarin; With lithium hexamethyldisilazane; In tetrahydrofuran; at -35 ℃; for 0.75h; Inert atmosphere;

(3R)-7-bromomethyl-5-oxo-8-(3-trifluoromethyl-phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester; In tetrahydrofuran; at -35 ℃; for 0.25h; Inert atmosphere;
DOI:10.1002/chem.201103936

Reference yield:

: 864365-18-4
(4R)-2-(3-(trifluoromethyl)benzyl)-4,5-dihydrothiazole-4-carboxylic acid methyl ester

: 1380299-33-1
(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.04 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -35 °C / Inert atmosphere

2.2: 0.25 h / -35 °C / Inert atmosphere

With trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1002/chem.201103936

Reference yield: 82.0%

: 1380299-33-1
(3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

: 1380299-37-5
(3R)-7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: (3R)-methyl 7-(2-(7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; Inert atmosphere;
DOI:10.1002/chem.201103936