(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Base Information

Chemical Name:(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester
CAS No.:870097-46-4
Molecular Formula:C₂₉H₃₉N₃O₁₀
Molecular Weight:589.643
Hs Code.:

Synonyms:(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Suppliers and Price of (5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

There total 4 articles about (5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870097-44-2
(5R,8R)-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 870097-46-4
(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo051639u

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 870097-46-4
(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane

2: Jones reagent / acetone / 12 h / Cooling with ice

3: sulfuric acid / dichloromethane / 12 h / Cooling with ice

4: water; ethanol / 72 h / Sealed tube

5: dmap / tetrahydrofuran / 12 h

With dmap; Jones reagent; sulfuric acid; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetone; 4: |Bucherer-Bergs Reaction;
DOI:10.1016/j.tetlet.2016.09.032

Reference yield:

: 130930-25-5
(R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid

: 870097-46-4
(5R,8R)-2,4-Dioxo-1,3,7-triaza-spiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Jones reagent / acetone / 12 h / Cooling with ice

2: sulfuric acid / dichloromethane / 12 h / Cooling with ice

3: water; ethanol / 72 h / Sealed tube

4: dmap / tetrahydrofuran / 12 h

With dmap; Jones reagent; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 3: |Bucherer-Bergs Reaction;
DOI:10.1016/j.tetlet.2016.09.032