(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

Base Information

Chemical Name:(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester
CAS No.:213907-41-6
Molecular Formula:C₁₉H₂₇ClO₅
Molecular Weight:370.873
Hs Code.:

Synonyms:(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

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Chemical Property of (2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

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Technology Process of (2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

There total 1 articles about (2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162439-40-9
(2R)-2-(tert-butoxycarbonylmethyl)-6-(phenylmethoxy)-hexanoic acid

: 213907-41-6
(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

Guidance literature:: (2R)-2-(tert-butoxycarbonylmethyl)-6-(phenylmethoxy)-hexanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

With tetrachloromethane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/jm990377j

Reference yield:

: 213907-41-6
(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

: 215607-12-8
(2S,3R)-7-Benzyloxy-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-2-(1-methyl-2-oxo-1,2-dihydro-quinolin-6-ylmethoxy)-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 36 h / 20 °C

2: NaH; NaI / tetrahydrofuran / 20 °C

3: TFA / CH₂Cl₂ / 20 °C

With sodium hydride; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Condensation / 2: Alkylation / 3: acidolysis;
DOI:10.1021/jm990377j

Reference yield:

: 213907-41-6
(2S,3R)-2-(4-Benzyloxy-butyl)-3-chloro-succinic acid 4-tert-butyl ester

: N²-[4-(N-hydroxyamino)-2R-(4-benzyloxy)butyl-3S-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)methoxysuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 36 h / 20 °C

2: NaH; NaI / tetrahydrofuran / 20 °C

3: TFA / CH₂Cl₂ / 20 °C

4: tBuMe₂SiONH₂; HOBT; EDCI / dimethylformamide / 20 °C

With O-(tert-butyldimethylsilanyl)hydroxylamine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Condensation / 2: Alkylation / 3: acidolysis / 4: Condensation;
DOI:10.1021/jm990377j